Allergen-specific T cells play an important role in the pathophysiology of atopic allergies.
Recently, cDNAs that encode many important allergens have been cloned and their amino …

BACKGROUND: Although antigen processing and presentation of allergens to CD4+ T
lymphocytes are key events in the pathophysiology of allergic disorders, they still remain …

T cells are major players in the initiation and perpetuation of the allergic immune response.
In this review, we summarize the current knowledge on allergen recognition by T …

We investigated the longevity of allergen-specific Th cells derived from patients suffering
from either allergic rhinitis or atopic dermatitis. T cell clones (TCC) specific for seasonal and …

BACKGROUND: Ninety-five percent of patients with mugwort allergy are sensitized to Art v
1, the sole major allergen in mugwort (Artemisia vulgaris) pollen. Sixty-nine percent of …

There is increasing experimental and structural support for the idea that the T cell receptor
CDR3 region makes primary contact with the peptide held in the MHC groove. As part of the …

Allergen-specific immunotherapy using peptides is an efficient treatment for allergic
diseases. Recent studies suggest that the induction of CD4+ regulatory T (Treg) cells might …

Background Allergen‐specific CD4+ T cells play an important regulatory role in atopic
allergy. Objective To investigate the human leucocyte antigen (HLA) restriction and T‐cell …

Background The involvement of CD4+ T cells in the pathophysiology of atopic disease is
well established. Objective To gain further insight into the activation requirements for …

Recent research has elucidated many of the immunologic mechanisms that underlie atopic
allergies. In particular, it has become clear that the role of CD4+ allergen‐specific T cells is …