Millions of individuals in the United States require long-term treatment with an oral
anticoagulant. For decades, vitamin K antagonists were the only oral option available; …

Introduction: Although significant progress has been made in high-throughput screening of
absorption, distribution, metabolism and excretion, and toxicity (ADME-Tox) properties in …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Introduction: Curcumin has been extensively studied for its anti-cancer properties. While a
diverse array of in vitro and preclinical research support the prospect of curcumin use as an …

Advances in genomic technologies have led to a wealth of information identifying genetic
polymorphisms in membrane transporters, specifically how these polymorphisms affect drug …

In recent years, an increasing number of clinical drug–drug interactions (DDIs) have been
attributed to inhibition of intestinal organic anion-transporting polypeptides (OATPs); …

ATP-binding cassette transporter G2 (ABCG2) is a plasma membrane protein that regulates
the pharmacokinetics of a variety of drugs and serum uric acid (SUA) levels in humans …

This white paper examines recent progress, applications, and challenges in predicting
unbound and total tissue and intra/subcellular drug concentrations using in vitro and …

This review provides a practical clinical perspective on the relevance of hepatic transporters
in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis is placed on …

Mechanistic understanding of complex clinical drug–drug interactions (DDI s) with potential
involvement of multiple elimination pathways has been challenging, especially given the …