Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and
eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones …

Regulation of RNA processing contributes profoundly to tissue development and physiology.
Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte …

Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed
in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression …

The ability of regulatory T (Treg) cells to control the immune response and limit the
development of autoimmune diseases is determined by distinct molecular processes, which …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the
dysregulation of B cell subpopulation and function. Recent studies have suggested a …

Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which
regulate splice site recognition and spliceosome assembly during precursor messenger …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by a
profound immune dysregulation and the presence of a variety of autoantibodies. Aberrant …

The human immune response is a complex process that responds to numerous exogenous
antigens in preventing infection by microorganisms, as well as to endogenous components …

Invariant natural killer T (iNKT) cells are highly conserved innate-like T lymphocytes that
originate from CD4+ CD8+ double-positive (DP) thymocytes. Here, we report that …