Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
Aberrant calcium signals in reactive astrocytes: a key process in neurological disorders
E Shigetomi, K Saito, F Sano, S Koizumi - International journal of …, 2019 - mdpi.com
Astrocytes are abundant cells in the brain that regulate multiple aspects of neural tissue
homeostasis by providing structural and metabolic support to neurons, maintaining synaptic …
homeostasis by providing structural and metabolic support to neurons, maintaining synaptic …
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development
Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are
implicated in diverse psychiatric and neurodegenerative diseases and are an emerging …
implicated in diverse psychiatric and neurodegenerative diseases and are an emerging …
Astrocytes: integrators of arousal state and sensory context
The integration of external information with the internal state of the body is central to the
survival of virtually every multicellular organism. However, a complete picture of the …
survival of virtually every multicellular organism. However, a complete picture of the …
Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their
differentiation into neural lineages is a revolutionary experimental system for studying …
differentiation into neural lineages is a revolutionary experimental system for studying …
FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors
Parvalbumin interneurons (PVIs) are affected in many psychiatric disorders including
schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk …
schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk …
The molecular functions of MeCP2 in Rett syndrome pathology
MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription.
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …
MECP2 and the biology of MECP2 duplication syndrome
SR D'Mello III - Journal of Neurochemistry, 2021 - Wiley Online Library
Abstract MECP2 duplication syndrome (MDS), a rare X‐linked genomic disorder affecting
predominantly males, is caused by duplication of the chromosomal region containing the …
predominantly males, is caused by duplication of the chromosomal region containing the …