Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by
cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in …

TRPV4 is a widely expressed cation channel of the 'transient receptor potential'(TRP) family
that is related to the vanilloid receptor VR1 (TRPV1). It functions as a Ca2+ entry channel …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Calcium influx in nonexcitable cells regulates such diverse processes as exocytosis,
contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant …

The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established
the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways …

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …

Blood flow and blood pressure are determined by an integration of reflex, humoral, and local
vascular control mechanisms. Knowledge of these mechanisms has mushroomed over the …

Rapid to moderately rapid changes in intracellular Ca2+ concentration, or Ca2+ signals,
control a variety of critical cellular functions in the immune system. These signals are …

Nitric oxide (· NO) signaling pathways and lipid oxidation reactions are of central importance
in both the maintenance of vascular homeostasis and the progression of vascular disease …