The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Objective: Glycerol constitutes an important metabolite for the control of lipid accumulation
and glucose homeostasis. The impact of obesity and obesity-associated type 2 diabetes as …

Diabetes increases the reabsorption of Na+ (TNa) and glucose via the sodium-glucose
cotransporter SGLT2 in the early proximal tubule (S1-S2 segments) of the renal cortex …

Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins
that allow the movement of water and other small solutes, especially glycerol, through cell …

Insulin has been shown to have antinatriuretic actions in humans and animal models.
Moreover, endogenous hyperinsulinemia and insulin infusion have been correlated to …

Colitis is associated with alterations in electrolyte and water transport. These changes give
rise to some of the symptoms experienced by patients with colitis. Alterations in fluid flux may …

The exact distributions of the different salt transport systems along the human cortical distal
nephron are unknown. Immunohistochemistry was performed on serial cryostat sections of …

Objective: To review the causes of cerebral edema in diabetic ketoacidosis (CEDKA),
including pathophysiology, risk factors, and proposed mechanisms, to review the diagnosis …

Diabetic nephropathy (DN) is a microangiopathic complication of diabetes mellitus (DM)
affecting one‐third of diabetic patients. The large variability in the clinical presentation of …