[HTML][HTML] The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
inputs—which include both nutrient availability as a result of diet and growth factor signalling …
[HTML][HTML] Sex disparities matter in cancer development and therapy
Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …
molecular and genomic therapies. Currently, whether patients with non-reproductive …
[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan
E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …
[HTML][HTML] UTX condensation underlies its tumour-suppressive activity
UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important
tumour suppressor that is frequently mutated in human cancers. However, as the …
tumour suppressor that is frequently mutated in human cancers. However, as the …
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences
MI Cheng, JH Li, L Riggan, B Chen, RY Tafti… - Nature …, 2023 - nature.com
Viral infection outcomes are sex biased, with males generally more susceptible than
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …
[HTML][HTML] KDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1,
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder
cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential in the …
cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential in the …
Lysine demethylase KDM6A in differentiation, development, and cancer
ABSTRACT Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …
family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B …
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …
passenger mutations, which occur as byproducts of cancer development. The cancer …
[HTML][HTML] Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …
differences lies in the sex chromosomes. Although the functions of the X chromosome …