Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is
overexpressed in many epithelial malignancies and correlates with cancer progression …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer, the third leading
cause of cancer-related deaths, and has been on the rise among young adults in the United …

Increasing evidence has linked claudins to signal transduction and tumorigenesis. The
expression of claudins is frequently dysregulated in the context of neoplastic transformation …

The barrier and fence functions of the claudin protein family are fundamental to tissue
integrity and human health. Increasing evidence has linked claudins to signal transduction …

The Hippo pathway is an evolutionarily conserved pathway that serves to promote cell death
and differentiation while inhibiting cellular proliferation across species. The downstream …

Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis because it is
often detected at an advanced stage, and drug resistance interferes with treatment …

Purpose Although there is an established role for microbiome dysbiosis in the pathobiology
of colorectal cancer (CRC), CRC patients of various race/ethnicities demonstrate distinct …

Colorectal cancer (CRC) is a common cancer, with a concerning rise in early-onset CRC
cases, signalling a shift in disease epidemiology. Whilst our understanding of the molecular …

Abstract Background First identified in Drosophila melanogaster, the Hippo pathway is
considered a major regulatory cascade controlling tissue homeostasis and organ …

Background Benign prostatic hyperplasia (BPH) is a common disease in older men
worldwide. However, there is currently no effective treatment for BPH. Bushen Tongluo …