Mechanism of cyclosporine A nephrotoxicity: Oxidative stress, autophagy, and signalings

Q Wu, X Wang, E Nepovimova, Y Wang, H Yang… - Food and chemical …, 2018 - Elsevier
Cyclosporine A (CsA) is a widely used immunosuppressive agent that greatly reduces the
rates of kidney-, heart-, and liver-transplant rejection. However, CsA nephrotoxicity is a …

Assessment of risk factors for acute graft-versus-host disease post-hematopoietic stem cell transplantation: a retrospective study based on a proportional odds model …

L Xue, L Song, X Yu, X Yang, F Xia… - Therapeutic …, 2023 - journals.sagepub.com
Background: Acute graft-versus-host disease (aGVHD) is a major complication following
hematopoietic stem cell transplantation (HSCT). Objective: This study aimed to explore the …

Liraglutide and Resveratrol alleviated cyclosporin A induced nephrotoxicity in rats through improving antioxidant status, apoptosis and pro-inflammatory markers

HS Kheira, GR Elsayed, M El-Adl - Biochemical and Biophysical Research …, 2024 - Elsevier
The recent study delves into the role of both liraglutide and/or resveratrol on the
nephropathic affection in rats treated with cyclosporine A (CsA). Rats were intoxicated with …

Effects of Triazole Antifungal Agents on the Plasma Concentration and Dosage of Cyclosporin in Patients with Aplastic Anaemia

Y Tian, Y Song, Y Qiao, L Song, Q Zhao… - Journal of Clinical …, 2024 - Wiley Online Library
Objectives. This study aimed to investigate the effects of different triazole antifungal agents
on the blood concentration and dosage of cyclosporine (CsA) in patients with aplastic …

Multicenter-based population pharmacokinetic analysis of ciclosporin in hematopoietic stem cell transplantation patients

L Xue, W Zhang, J Tian, L Liu, H Yan, W Zhang… - Pharmaceutical …, 2020 - Springer
Purpose To explore the contribution of physiological characteristics to variability in
ciclosporin pharmacokinetics in hematopoietic stem cell transplantation patients. Methods …

Baicalin reduces ciclosporin bioavailability by inducing intestinal p-glycoprotein in rats

X Tian, Y Chang, J Wei, R Liu, L Wang… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives To investigate the effects of multiple doses of baicalin (BG) on the
pharmacokinetics of ciclosporin (CsA) in rats and the potential mechanisms. Methods …

Effect of posaconazole on the concentration of intravenous and oral cyclosporine in patients undergoing hematopoietic stem cell transplantation

LE Zhu, HP Huang, YP Cai, Y Wang, BH Xu… - European Journal of …, 2022 - Springer
Purpose This study aimed to investigate the interactions between posaconazole (POS) and
intravenously/orally administered cyclosporine A (CsA) in allogeneic hematopoietic stem …

Accidental overdose of oral cyclosporine in haematopoietic stem cell transplantation: a case report and literature review

A Tafazoli - Drug Safety-Case Reports, 2015 - Springer
A 26-year-old woman developed symptoms of acute toxicity during cyclosporine (CsA)
therapy for graft-versus-host disease prophylaxis. The standard regimen included CsA in a …

Impact of cyclosporine‐A concentration in T‐cell replete haploidentical allogeneic stem cell transplantation

X Yang, S Yang, A Sun, H Qiu, X Tang… - Clinical …, 2018 - Wiley Online Library
This paper aims to study whether cyclosporine‐A (CSA) levels have an impact on the clinical
outcome of patients with T‐cell replete haploidentical allogeneic hematopoietic stem cell …

Inhibition of peptidyl‑prolyl cis‑trans isomerase B mediates cyclosporin A‑induced apoptosis of islet β cells

X Wei, D Zhu, C Feng, G Chen… - Experimental and …, 2018 - spandidos-publications.com
Cyclosporin A (CsA) is widely used as an immunosuppressor in the context of organ
transplantation or autoimmune disorders. Recent studies have revealed the detrimental …