Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

Members of the Tc1/mariner superfamily of transposons isolated from fish appear to be
transpositionally inactive due to the accumulation of mutations. Molecular phylogenetic data …

We report here development of a novel gene trap method in zebrafish using the Tol2
transposon system. First, we established a highly efficient transgenesis method in which a …

Genome sequencing has yielded a plethora of new genes the function of which can be
unravelled through comparative genomic approaches. Increasingly, developmental …

Teleost fish, which roughly make up half of the extant vertebrate species, exhibit an amazing
level of biodiversity affecting their morphology, ecology and behaviour as well as many other …

The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …

The Tol2 element is a naturally occurring active transposable element found in vertebrate
genomes. The Tol2 transposon system has been shown to be active from fish to mammals …

The Tol2 element of the medaka fish Oryzias latipes belongs to the hAT family of
transposons (hobo/Ac/Tam3). We report here identification of a functional transposase of …

Jellyfish are radially symmetric organisms without a brain that arose more than 500 million
years ago. They achieve organismal behaviors through coordinated interactions between …