Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

The localization of soluble endoplasmic reticulum (ER) chaperones in the cell organelle is
mediated by the C‐terminal KDEL (lysine, aspartic acid, glutamic acid and leucine) motif …

To increase the productivity of rCHO cells, many cell engineering approaches have been
demonstrated that over-express or knockout a specific gene to achieve increased titers. In …

Therapeutic antibodies, with their high specificity and flexibility, are responsible for treating
many acute and chronic diseases. In particular, monoclonal antibodies remain the largest …

PhD thesis_20210825 Page 1 Title Investigation of ER retention machinery in CHO cells for
understanding its biology and probable IgG production bottlenecks Author(s) Samy …

Os resultados aqui obtidos demonstram que engenharia metabólica é uma estratégia
valiosa para o melhoramento de produção de retrovírus recombinantes. Três dos cinco …