Bioorthogonal cleavage chemistry has been rapidly emerging as a powerful tool for
manipulation and gain-of-function studies of biomolecules in living systems. While the initial …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Chemical synthesis of proteins with aggregable or colloidal peptide segments presents a
formidable task, as such peptides prove to be difficult for both solid-phase peptide synthesis …

Native chemical ligation (NCL) provides a powerful solution to assemble proteins with
precise chemical features, which enables a detailed investigation of the protein structure …

Efficient intracellular delivery of protein drugs and tumor‐specific activation of protein
functions are critical toward anti‐cancer protein therapy. However, an omnipotent protein …

Engineering near‐infrared (NIR) light‐sensitive enzymes remains a huge challenge. A
photothermal effect‐associated method is developed for tailoring the enzymatic activity of …

Protein chemical synthesis offers useful and otherwise-difficulty-to-obtain
biomacromolecules for biological and pharmaceutical studies. Recently, the hydrazide …

Photoremovable protecting groups are important for a wide range of applications in peptide
chemistry. Using Fmoc-Cys (Bhc-MOM)-OH, peptides containing a Bhc-protected cysteine …

Naturally abundant quinones are important molecules, which play essential roles in various
biological processes due to their reduction potential. In contrast to their universality, the …

With the growing requirement for otherwise-difficult-to-obtain proteins, it is necessary to
develop more efficient chemical protein synthesis methods for rapid access to designed …