Form follows function: nanoparticle shape and its implications for nanomedicine

C Kinnear, TL Moore, L Rodriguez-Lorenzo… - Chemical …, 2017 - ACS Publications
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …

Physical principles of nanoparticle cellular endocytosis

S Zhang, H Gao, G Bao - ACS nano, 2015 - ACS Publications
This review article focuses on the physiochemical mechanisms underlying nanoparticle
uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between …

Entry of nanoparticles into cells: The importance of nanoparticle properties

J Zhao, MH Stenzel - Polymer Chemistry, 2018 - pubs.rsc.org
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …

Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …

S Ruan, Y Zhou, X Jiang, H Gao - Advanced Science, 2021 - Wiley Online Library
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

Cellular uptake of nanoparticles as determined by particle properties, experimental conditions, and cell type

K Kettler, K Veltman, D van De Meent… - Environmental …, 2014 - Wiley Online Library
The increased application of nanoparticles (NPs) is increasing the risk of their release into
the environment. Although many toxicity studies have been conducted, the environmental …

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine

AM Alkilany, L Zhu, H Weller, A Mews, WJ Parak… - Advanced Drug Delivery …, 2019 - Elsevier
Nanoparticles modified with ligands for specific targeting towards receptors expressed on
the surface of target cells are discussed in literature towards improved delivery strategies. In …

Understanding cellular interactions with nanomaterials: Towards a rational design of medical nanodevices

F Villanueva-Flores, A Castro-Lugo, OT Ramírez… - …, 2020 - iopscience.iop.org
Biomedical applications increasingly require fully characterized new nanomaterials. There is
strong evidence showing that nanomaterials not only interact with cells passively but also …

Nexus between in silico and in vivo models to enhance clinical translation of nanomedicine

FM Kashkooli, M Soltani, M Souri, C Meaney… - Nano Today, 2021 - Elsevier
In cancer, one of the main barriers to effective chemotherapy is inefficient drug delivery. The
delivery of drugs to solid tumors involves various biochemical, biophysical, and mechanical …

Effect of micro-and nanoparticle shape on biological processes

H Hadji, K Bouchemal - Journal of Controlled Release, 2022 - Elsevier
In the drug delivery field, there is beyond doubt that the shape of micro-and nanoparticles
(M&NPs) critically affects their biological fate. Herein, following an introduction describing …

Physiologically based pharmacokinetic modeling of nanoparticles

M Li, KT Al-Jamal, K Kostarelos, J Reineke - ACS nano, 2010 - ACS Publications
Rapid expansion of nanoparticle research demands new technologies that will enable better
interpretation of experimental data and assistance in the rational design of future …