The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

Although tumours initiate from oncogenic changes in a cancer cell, subsequent tumour
progression and therapeutic response depend on interactions between the cancer cells and …

The Cancer Genome Atlas (TCGA) has profiled over 10,000 tumors across 33 different
cancer-types for many genomic features, including gene expression levels. Gene …

Primary cilia are microtubule‑based organelles that are expressed on almost all mammalian
cells. It has become apparent that these structures are important signaling hubs that serve …

Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can
eventually result in the development of ciliopathies: pathologically diverse diseases that …

Since the beginning of the millennium, research in primary cilia has revolutionized our way
of understanding how cells integrate and organize diverse signaling pathways during …

Primary cilia detect extracellular cues and transduce these signals into cells to regulate
proliferation, migration, and differentiation. Here, the function of primary cilia as signaling …

The primary cilium is a solitary, nonmotile and transitory appendage that is present in
virtually all mammalian cells. Our knowledge of its ultrastructure and function is the result of …

Background Primary cilia are microtubule-based organelles that protrude from the cell
surface. Primary cilia play a critical role in development and disease through regulation of …

Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Little is
known about the role of primary cilia in preinvasive and invasive prostate cancer. However …