Free radicals and other oxidants have gained importance in the field of biology due to their
central role in various physiological conditions as well as their implication in a diverse range …

Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological
conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating …

Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …

Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding
evolutionary and molecular processes. In this report, we analyze spontaneous mutations …

Inflammation can be induced by chronic infection, inflammatory diseases and
physicochemical factors. Chronic inflammation is estimated to contribute to approximately …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Although DNA is the carrier of genetic information, it has limited chemical stability.
Hydrolysis, oxidation and nonenzymatic methylation of DNA occur at significant rates in vivo …

Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are
common in diverse types of human cancer. The p53 mutational spectrum differs among …