Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a
recipient's immune system would abolish the requirement for immunosuppressive drugs or …

Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy.
Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Trastuzumab, a targeted anti-human epidermal-growth-factor receptor-2 (HER2) monoclonal
antibody, represents a mainstay in the treatment of HER2-positive (HER2+) breast cancer …

Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be
achieved without chronic immunosuppression or encapsulation. Existing genetic …

Manufacturing autologous chimeric antigen receptor (CAR) T cell therapeutics is complex,
and many patients experience treatment delays or cannot be treated at all. Although current …

The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted
interest in its role in cancer biology and potential as a therapeutic target. Decreased …