Systematic review and meta-analysis of statin use and mortality, intensive care unit admission and requirement for mechanical ventilation in COVID-19 patients

US Lao, CF Law, DT Baptista-Hon… - Journal of Clinical …, 2022 - mdpi.com
There is mounting evidence that statin use is beneficial for COVID-19 outcomes. We
performed a systematic review and meta-analysis to evaluate the association between statin …

Statin use in relation to COVID-19 and other respiratory infections: Muscle and other considerations

BA Golomb, JH Han, PH Langsjoen… - Journal of Clinical …, 2023 - mdpi.com
Statins have been widely advocated for use in COVID-19 based on large favorable
observational associations buttressed by theoretical expected benefits. However, past …

Protective effects of statins on COVID-19 risk, severity and fatal outcome: a nationwide Swedish cohort study

A Santosa, S Franzén, J Nåtman, B Wettermark… - Scientific Reports, 2022 - nature.com
The impact of statins on COVID-19 remains unclear. This study aims to investigate whether
statin exposure assessed both in the population and in well-defined cohorts of COVID-19 …

Association of statins for primary prevention of cardiovascular diseases with hospitalization for COVID‐19: A nationwide matched population‐based cohort study

K Bouillon, B Baricault, L Semenzato… - Journal of the …, 2022 - Am Heart Assoc
Background There is little evidence on the relationship between statin use and the risk of
hospitalization attributable to COVID‐19. Methods and Results The French National …

Antivirals against (re) emerging flaviviruses: should we target the virus or the host?

MJ Pérez-Pérez, JC Saiz, EM Priego… - ACS Medicinal …, 2021 - ACS Publications
The COVID pandemic has evidenced how vulnerable we are to emerging infectious
diseases and how short our current armamentarium is. Flavivirus, single stranded RNA …

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective

B Tan, KY Chin - Frontiers in Physiology, 2023 - frontiersin.org
Myopathy is the most common side effect of statins, but it has not been addressed effectively.
In anticipation of its wider use as a small molecule to complement the current COVID-19 …

Routine statins use is associated with less adverse outcome in patients above 70 years of age admitted to hospital with COVID-19

E Izkhakov, Y Vilian, A Buch, V Denysov, D Namouz… - BMC geriatrics, 2023 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to multiorgan insufficiency and …

Biological actions, implications, and cautions of statins therapy in COVID-19

C Liu, W Yan, J Shi, S Wang, A Peng, Y Chen… - Frontiers in …, 2022 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) showed worse prognosis and higher mortality in
individuals with obesity. Dyslipidemia is a major link between obesity and COVID-19 …

Randomized phase II clinical trial of ruxolitinib plus simvastatin in COVID19 clinical outcome and cytokine evolution

J Garcia-Donas, D Martínez-Urbistondo… - Frontiers in …, 2023 - frontiersin.org
Background Managing the inflammatory response to SARS-Cov-2 could prevent respiratory
insufficiency. Cytokine profiles could identify cases at risk of severe disease. Methods We …

The association between statin and COVID-19 adverse outcomes: national COVID-19 cohort in South Korea

R Chow, J Lee, H Noh, J Lee, HJ Shin, YG Choi - medRxiv, 2021 - medrxiv.org
Background There currently exists limited and conflicting clinical data on the use of statins
amongst COVID-19 patients. Given the both paucity and lack of consensus among data on …