A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Adaptation is one of physiology's fundamental tenets, operating not only at the level of
species, as Darwin proposed, but also at the level of tissues, cells, molecules and, perhaps …

MicroRNAs (miRNAs) are∼ 22 nucleotides long, noncoding RNAs that control cellular
function by either degrading mRNAs or arresting their translation. To understand their …

Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …

Resveratrol, a stilbene formed in many plants in response to various stressors, elicits
multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have …

Increased levels of interleukin‐6 (IL‐6) play a role in post‐ischemic cerebral inflammation. IL‐
6 binding to its receptors induces phosphorylation of the receptor associated janus kinases …

Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Heat shock proteins (Hsps) are highly conserved and under physiological conditions act as
molecular chaperones and/or have anti-apoptotic activities. Expression in the brain of two …

Multifaceted cellular, biochemical, and molecular monitoring of proteins and lipids is logical
as an adjunct to guiding therapies and improving outcomes in traumatic and ischemic brain …

Peroxisome proliferator-activated receptor (PPAR)-γ is a ligand-activated transcription factor
of nuclear hormone receptor superfamily. Thiazolidinedione rosiglitazone is a potent agonist …