Long-acting parenteral drug delivery systems for the treatment of chronic diseases
The management of chronic conditions often requires patients to take daily medication for an
extended duration. However, the need for daily dosing can lead to nonadherence to the …
extended duration. However, the need for daily dosing can lead to nonadherence to the …
Prodrug approaches for the development of a long-acting drug delivery systems
ST Chien, IT Suydam, KA Woodrow - Advanced Drug Delivery Reviews, 2023 - Elsevier
Long-acting formulations are designed to reduce dosing frequency and simplify dosing
schedules by providing an extended duration of action. One approach to obtain long-acting …
schedules by providing an extended duration of action. One approach to obtain long-acting …
Recent advances in lipid-based long-acting injectable depot formulations
Long-acting injectable (LAIs) delivery systems sustain the drug therapeutic action in the
body, resulting in reduced dosage regimen, toxicity, and improved patient compliance. Lipid …
body, resulting in reduced dosage regimen, toxicity, and improved patient compliance. Lipid …
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges
V Agrahari, SM Anderson, MM Peet… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP)
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …
has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting …
[HTML][HTML] Advances in long-acting slow effective release antiretroviral therapies for treatment and prevention of HIV infection
Adherence to daily oral antiretroviral therapy (ART) is a barrier to both treatment and
prevention of human immunodeficiency virus (HIV) infection. To overcome limitations of life …
prevention of human immunodeficiency virus (HIV) infection. To overcome limitations of life …
HIV-1 integrase strand transfer inhibitors and neurodevelopment
Children born to mothers, with or at risk, of human immunodeficiency virus type-1 (HIV-1)
infection are on the rise due to affordable access of antiretroviral therapy (ART) to pregnant …
infection are on the rise due to affordable access of antiretroviral therapy (ART) to pregnant …
Long-acting dolutegravir formulations prevent neurodevelopmental impairments in a mouse model
The World Health Organization has recommended dolutegravir (DTG) as a preferred first-
line treatment for treatment naive and experienced people living with human …
line treatment for treatment naive and experienced people living with human …
Polymer Delivery Systems for Long-Acting Antiretroviral Drugs
The success of long-acting (LA) drug delivery systems (DDSs) is linked to their
biocompatible polymers. These are used for extended therapeutic release. For treatment or …
biocompatible polymers. These are used for extended therapeutic release. For treatment or …
Polymer–prodrug conjugates as candidates for degradable, long-acting implants, releasing the water-soluble nucleoside reverse-transcriptase inhibitor emtricitabine
C Liu, FY Hern, A Shakil, K Temburnikar… - Journal of Materials …, 2023 - pubs.rsc.org
Circulating, soluble polymer–drug conjugates have been utilised for many years to aid the
delivery of sensitive, poorly-soluble or cytotoxic drugs, prolong circulation times or minimise …
delivery of sensitive, poorly-soluble or cytotoxic drugs, prolong circulation times or minimise …
3D printing of dolutegravir-loaded polylactide filaments as a long-acting implantable system for HIV treatment
BNV Hari, T Makowski, P Sowiński, A Domańska… - International Journal of …, 2024 - Elsevier
Abstract 3D printing was used to prepare implantable systems or tablets loaded with
dolutegravir to explore their potential as long-acting implantables (LAIs). Our strategy relies …
dolutegravir to explore their potential as long-acting implantables (LAIs). Our strategy relies …