Exerkines in health, resilience and disease

LS Chow, RE Gerszten, JM Taylor… - Nature Reviews …, 2022 - nature.com
The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …

Update on the effects of physical activity on insulin sensitivity in humans

SR Bird, JA Hawley - BMJ open sport & exercise medicine, 2017 - bmjopensem.bmj.com
Purpose and methods This review presents established knowledge on the effects of physical
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …

Precision exercise medicine: understanding exercise response variability

R Ross, BH Goodpaster, LG Koch… - British journal of sports …, 2019 - bjsm.bmj.com
There is evidence from human twin and family studies as well as mouse and rat selection
experiments that there are considerable interindividual differences in the response of …

Exercise training for patients with type 2 diabetes and cardiovascular disease: What to pursue and how to do it. A Position Paper of the European Association of …

H Kemps, N Kränkel, M Dörr… - European journal of …, 2019 - journals.sagepub.com
Patients with type 2 diabetes mellitus suffer from dysregulation of a plethora of
cardiovascular and metabolic functions, including dysglycaemia, dyslipidaemia, arterial …

Frailty status modifies the efficacy of exercise training among patients with chronic heart failure and reduced ejection fraction: an analysis from the HF-ACTION trial

A Pandey, MW Segar, S Singh, GR Reeves… - Circulation, 2022 - Am Heart Assoc
Background: Supervised aerobic exercise training (ET) is recommended for stable
outpatients with heart failure (HF) with reduced ejection fraction (HFrEF). Frailty, a syndrome …

Type 2 diabetes and reduced exercise tolerance: a review of the literature through an integrated physiology approach

L Nesti, NR Pugliese, P Sciuto, A Natali - Cardiovascular Diabetology, 2020 - Springer
The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) is well
established. Early in the course of the diabetic disease, some degree of impaired exercise …

[HTML][HTML] The limits of exercise physiology: from performance to health

BM Gabriel, JR Zierath - Cell metabolism, 2017 - cell.com
Many of the established positive health benefits of exercise have been documented by
historical discoveries in the field of exercise physiology. These investigations often assess …

Exercise training response heterogeneity: physiological and molecular insights

LM Sparks - Diabetologia, 2017 - Springer
The overall beneficial effects of exercise are well studied, but why some people do not
respond favourably to exercise is less understood. The National Institutes of Health …

Understanding the variation in exercise responses to guide personalized physical activity prescriptions

J Noone, JM Mucinski, JP DeLany, LM Sparks… - Cell Metabolism, 2024 - cell.com
Understanding the factors that contribute to exercise response variation is the first step in
achieving the goal of developing personalized exercise prescriptions. This review discusses …

Cardiac rehabilitation fitness changes and subsequent survival

A De Schutter, S Kachur, CJ Lavie… - … Journal-Quality of …, 2018 - academic.oup.com
Aims Assessments of cardiac rehabilitation (CR) in coronary heart disease (CHD) cohorts
usually examine mortality in aggregate. This study examines the prognosis and …