Conspectus Modified nucleosides show therapeutic promise for antiviral therapies.
However, issues including the emergence of drug resistance, toxicity, and coinfections have …

Antiviral therapies are integral in the fight against SARS‐CoV‐2 (ie severe acute respiratory
syndrome coronavirus 2), the causative agent of COVID‐19. Antiviral therapeutics can be …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a
global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) …

Outbreaks of coronaviruses (CoVs), especially severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2), have posed serious threats to humans and animals, which …

Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral
mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however …

Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …

Introduction Molnupiravir (MOV) is a broad-spectrum oral antiviral agent approved for the
treatment of COVID-19. The results from in vitro and in vivo studies suggested MOV activity …

Since the first appearance of a novel coronavirus pneumonia (NCP) caused by a novel
human coronavirus, and especially after the infection started its rapid spread over the world …

The COVID-19 pandemic has spurred intense research efforts to identify effective treatments
for SARS-CoV-2. In silico studies have emerged as a powerful tool in the drug discovery …

Sixteen chemically varied metabolites were isolated from the bulbs of Hippeastrum vittatum
(L'Her.) Herb., including eight flavonoids [3′-methyl isoliquiritigenin (2), 7-hydroxyflavan …