Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Dendritic cells (DCs) are currently considered to be of utmost importance for orchestrating
appropriate immune responses in vivo, and play critical roles in maintaining the distinction …

During an immune response to microbial infection, CD8+ T cells give rise to distinct classes
of cellular progeny that coordinately mediate clearance of the pathogen and provide long …

Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors
(ICIs) are only efficacious for a subset of patients. To gain a better understanding of the …

Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke,
aortic arch syndrome, and aortic aneurysm. The disease is often refractory to …

Breast cancer is now the most frequently diagnosed malignancy, and metastasis remains
the leading cause of death in breast cancer. However, little is known about the dynamic …

Tissue-resident memory T cells (TRM) contained at sites of previous infection provide local
protection against reinfection. Whether they form and function in organ transplants where …

Analyses of healthy tissue reveal signatures that identify resident memory CD8+ T cells
(TRM), which survey tissues without recirculating. The density of TRM phenotype cells within …

Statistical analysis of single cell RNA-sequencing (scRNA-seq) data is hindered by high
levels of technical noise and inflated zero counts. One promising approach for addressing …

Activating the inherent stimulator of interferon gene (STING) pathway of cancer cells can
inhibit tumor growth but can also induce protective autophagy of tumor cells to inhibit the …