Patient deaths resulting from cardiovascular diseases are increasing across the globe,
posing the greatest risk to patients in developed countries. Myocardial infarction, as a result …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Cancer stem cells (CSCs), with their self-renewal ability and multilineage differentiation
potential, are a critical subpopulation of tumor cells that can drive tumor initiation, growth …

Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

We report here homologous recombination (HR)-mediated gene targeting of two different
genes in human iPS cells (hiPSCs) and human ES cells (hESCs). HR-mediated correction of …

Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic
cancer progression. MDSC regulation is widely variable even among patients harbouring …

Human induced pluripotent stem (iPS) cells derived from somatic cells hold promise to
develop novel patient-specific cell therapies and research models for inherited and acquired …

The differentiation of stem cells into smooth muscle cells (SMCs) plays an important role in
vascular development and remodeling. In addition, stem cells represent a potential source of …

Notch signaling is often and aberrantly activated by hypoxia during tumor progression;
however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis …