Vanadium in diabetes: 100 years from Phase 0 to Phase I
KH Thompson, C Orvig - Journal of inorganic biochemistry, 2006 - Elsevier
A little over one hundred years ago, a vanadium-containing compound was assessed
clinically for use in treatment of human diabetic patients. The results were somewhat …
clinically for use in treatment of human diabetic patients. The results were somewhat …
Binding of vanadium ions and complexes to proteins and enzymes in aqueous solution
The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …
biology, as well as the design of new vanadium-based species for catalysis, materials …
Vanadium and proteins: Uptake, transport, structure, activity and function
Vanadium is an element ubiquitously present in our planet's crust and thus there are several
organisms that use vanadium for activity or function of proteins. Examples are the vanadium …
organisms that use vanadium for activity or function of proteins. Examples are the vanadium …
Toxicology of vanadium compounds in diabetic rats: the action of chelating agents on vanadium accumulation
JL Domingo, M Gomez, DJ Sanchez, JM Llobet… - Molecular and cellular …, 1995 - Springer
The possible use of vanadium compounds in the treatment of diabetic patients is now being
evaluated. However, previously to establish the optimal maximum dose for diabetes therapy …
evaluated. However, previously to establish the optimal maximum dose for diabetes therapy …
Interaction of antidiabetic vanadium compounds with hemoglobin and red blood cells and their distribution between plasma and erythrocytes
The interaction of VIVO2+ ion with hemoglobin (Hb) was studied with the combined
application of spectroscopic (EPR), spectrophotometric (UV–vis), and computational (DFT …
application of spectroscopic (EPR), spectrophotometric (UV–vis), and computational (DFT …
Micronutrients and antioxidants in the progression of diabetes
KH Thompson, DV Godin - Nutrition Research, 1995 - Elsevier
Evidence for changes in trace mineral and vitamin metabolism as a consequence of
diabetes pathophysiology is reviewed. Emphasis is on those micronutrients which have a …
diabetes pathophysiology is reviewed. Emphasis is on those micronutrients which have a …
Mechanisms of vanadate-induced cellular toxicity: role of cellular glutathione and NADPH
LS Capella, MR Gefé, EF Silva… - Archives of Biochemistry …, 2002 - Elsevier
Besides its insulin-mimetic effects, vanadate is also known to have a variety of physiological
and pharmacological properties, varying from induction of cell growth to cell death and is …
and pharmacological properties, varying from induction of cell growth to cell death and is …
Oral vanadium administration to streptozotocin-diabetic rats has marked negative side-effects which are independent of the form of vanadium used
In the present investigation, the effects of oral administration of sodium metavanadate,
sodium orthovanadate and vanadyl sulphate to alleviate some signs of diabetes in …
sodium orthovanadate and vanadyl sulphate to alleviate some signs of diabetes in …
Vanadyl (IV) and vanadate (V) binding to selected endogenous phosphate, carboxyl, and amino ligands; calculations of cellular vanadium species distribution
BR Nechay, LB Nanninga, PSE Nechay - Archives of Biochemistry and …, 1986 - Elsevier
Vanadium enters cells as vanadate (V) where it is reduced to vanadyl (IV), VO 2+. Vanadate
species at plasma pH, H 2 VO 4−, and HVO 4 2− are referred to as VO 3−. To gain an insight …
species at plasma pH, H 2 VO 4−, and HVO 4 2− are referred to as VO 3−. To gain an insight …
Vanadium compounds as pro-inflammatory agents: effects on cyclooxygenases
J Korbecki, I Baranowska-Bosiacka, I Gutowska… - International journal of …, 2015 - mdpi.com
This paper discusses how the activity and expression of cyclooxygenases are influenced by
vanadium compounds at anticancer concentrations and recorded in inorganic vanadium …
vanadium compounds at anticancer concentrations and recorded in inorganic vanadium …