Vanadium in diabetes: 100 years from Phase 0 to Phase I

KH Thompson, C Orvig - Journal of inorganic biochemistry, 2006 - Elsevier
A little over one hundred years ago, a vanadium-containing compound was assessed
clinically for use in treatment of human diabetic patients. The results were somewhat …

Binding of vanadium ions and complexes to proteins and enzymes in aqueous solution

JC Pessoa, MFA Santos, I Correia, D Sanna… - Coordination Chemistry …, 2021 - Elsevier
The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …

Vanadium and proteins: Uptake, transport, structure, activity and function

JC Pessoa, E Garribba, MFA Santos… - Coordination chemistry …, 2015 - Elsevier
Vanadium is an element ubiquitously present in our planet's crust and thus there are several
organisms that use vanadium for activity or function of proteins. Examples are the vanadium …

Toxicology of vanadium compounds in diabetic rats: the action of chelating agents on vanadium accumulation

JL Domingo, M Gomez, DJ Sanchez, JM Llobet… - Molecular and cellular …, 1995 - Springer
The possible use of vanadium compounds in the treatment of diabetic patients is now being
evaluated. However, previously to establish the optimal maximum dose for diabetes therapy …

Interaction of antidiabetic vanadium compounds with hemoglobin and red blood cells and their distribution between plasma and erythrocytes

D Sanna, M Serra, G Micera, E Garribba - Inorganic Chemistry, 2014 - ACS Publications
The interaction of VIVO2+ ion with hemoglobin (Hb) was studied with the combined
application of spectroscopic (EPR), spectrophotometric (UV–vis), and computational (DFT …

Micronutrients and antioxidants in the progression of diabetes

KH Thompson, DV Godin - Nutrition Research, 1995 - Elsevier
Evidence for changes in trace mineral and vitamin metabolism as a consequence of
diabetes pathophysiology is reviewed. Emphasis is on those micronutrients which have a …

Mechanisms of vanadate-induced cellular toxicity: role of cellular glutathione and NADPH

LS Capella, MR Gefé, EF Silva… - Archives of Biochemistry …, 2002 - Elsevier
Besides its insulin-mimetic effects, vanadate is also known to have a variety of physiological
and pharmacological properties, varying from induction of cell growth to cell death and is …

Oral vanadium administration to streptozotocin-diabetic rats has marked negative side-effects which are independent of the form of vanadium used

JL Domingo, M Gomez, JM Llobet, J Corbella, CL Keen - Toxicology, 1991 - Elsevier
In the present investigation, the effects of oral administration of sodium metavanadate,
sodium orthovanadate and vanadyl sulphate to alleviate some signs of diabetes in …

Vanadyl (IV) and vanadate (V) binding to selected endogenous phosphate, carboxyl, and amino ligands; calculations of cellular vanadium species distribution

BR Nechay, LB Nanninga, PSE Nechay - Archives of Biochemistry and …, 1986 - Elsevier
Vanadium enters cells as vanadate (V) where it is reduced to vanadyl (IV), VO 2+. Vanadate
species at plasma pH, H 2 VO 4−, and HVO 4 2− are referred to as VO 3−. To gain an insight …

Vanadium compounds as pro-inflammatory agents: effects on cyclooxygenases

J Korbecki, I Baranowska-Bosiacka, I Gutowska… - International journal of …, 2015 - mdpi.com
This paper discusses how the activity and expression of cyclooxygenases are influenced by
vanadium compounds at anticancer concentrations and recorded in inorganic vanadium …