Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of
cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases …

The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …

We report here the purification of the third protein factor, Apaf-3, that participates in caspase-
3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9 …

Programmed cell death is a distinct genetic and biochemical pathway essential to
metazoans. An intact death pathway is required for successful embryonic development and …

Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We
identify DEPTOR as an mTOR-interacting protein whose expression is negatively regulated …

A cell-free system based on cytosols of normally growing cells is established that
reproduces aspects of the apoptotic program in vitro. The apoptotic program is initiated by …

Bcl-2 is an integral membrane protein located mainly on the outer membrane of
mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in …