Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

Norepinephrine is the principal vasopressor used to restore blood pressure in sepsis, but its
effects on intrarenal oxygenation are unknown. To clarify this, we examined renal cortical …

Objectives: Angiotensin II is an emerging therapy for septic acute kidney injury, but it is
unknown if its vasoconstrictor action induces renal hypoxia. We therefore examined the …

Objectives: To determine whether there is a decrease in renal cortical or medullary perfusion
and oxygenation in a conscious large animal model of hyperdynamic septic shock with …

Acute kidney injury (AKI) is a common complication following cardiac surgery performed on
cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology …

Renal medullary hypoxia may contribute to cardiac surgery–associated acute kidney injury
(AKI). However, the effects of cardiopulmonary bypass (CPB) on medullary oxygenation are …

Study objective To evaluate the impact of a dynamic arterial elastance guided
norepinephrine weaning strategy on the occurrence of acute kidney injury (AKI) in patients …

Kidney tissue hypoxia is detected in various kidney diseases and is considered to play an
important role in the pathophysiology of both AKI and CKD. Because of the characteristic …

Background Global and intra-renal perfusion and oxygenation may be affected by the choice
of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on …