Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …

Methylation of CpG dinucleotides plays a crucial role in the regulation of gene expression
and therefore in the development of different pathologies. Aberrant methylation has been …

Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune
responses in cancer, although the factors involved in PD-L1 regulation are poorly …

All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban
decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the …

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease with
variable severity. Patients experience frequent relapses where symptoms increase in …

Simple Summary Cancer cell lines are a defined population of cells, originally sourced from
tumour tissue, that can be maintained in culture for an extended period of time. They are a …

Sequencing-based genome-wide DNA methylation, gene expression studies and
associated data on paired colorectal cancer (CRC) primary and liver metastasis are very …

Background Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of
DNA from patients in cancer research. However, FFPE is a challenging material to work with …

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a
lifelong debilitating disease with a complex pathology not yet clearly defined. Susceptibility …

DNA methylation is well‐established as a major epigenetic mechanism that can control
gene expression and is involved in both normal development and disease. Analysis of high …