Early life stress (ELS) developmental effects have been widely studied by preclinical
researchers. Despite the growing body of evidence from ELS models, such as the maternal …

Genetic factors and early life adversity both play a major role in the etiology of mood and
anxiety disorders. Previous studies have shown that postnatal maternal separation (MS) can …

Childhood trauma is known to increase risk for emotional disorders and addiction. However,
little is currently understood about the neurodevelopmental basis of these effects, or how …

Stressful events in an early postnatal period have critical implications for the individual's life
and can increase later risk for psychiatric disorders. The aim of this study was to investigate …

BACKGROUND: Early experiences produce persistent changes in brain and behavioral
function. We investigate whether being reared in a communal nest (CN), a form of early …

Adolescence comes in association with puberty, when maturation and rearrangement of
major neurotransmitter pathways and functions are still taking place. The neurobiological …

Rationale While human depressive illness is indeed uniquely human, many of its symptoms
may be modeled in rodents. Based on human etiology, the assumption has been made that …

Currently, there is a lot of interest in cannabis use as a risk factor for the development of
schizophrenia. Cognitive dysfunction associated with long-term or heavy cannabis use is …

A disruption in normal brain development has been hypothesized to contribute to the
aetiology of major psychiatric disorders. According to the 'double-hit'hypothesis, mutant …

With advances in basic and clinical neuroscience, many gaps have appeared in the
traditional monoamine theory of depression that have led to reformulation of the hypotheses …