Plant-based biopharmaceutical engineering
L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …
Development of plant-made monoclonal antibodies against viral infections
Q Chen - Current opinion in virology, 2022 - Elsevier
Current plant-based systems offer multiple advantages for monoclonal antibody (mAb)
development and production beyond the traditional benefits of low cost and high scalability …
development and production beyond the traditional benefits of low cost and high scalability …
CRISPR/Cas9‐mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β‐1,2‐xylose and …
Plants offer fast, flexible and easily scalable alternative platforms for the production of
pharmaceutical proteins, but differences between plant and mammalian N‐linked glycans …
pharmaceutical proteins, but differences between plant and mammalian N‐linked glycans …
Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants
E Margolin, YJ Oh, M Verbeek, J Naude… - Plant Biotechnology …, 2020 - Wiley Online Library
Plant molecular farming (PMF) is rapidly gaining traction as a viable alternative to the
currently accepted paradigm of producing biologics. While the platform is potentially …
currently accepted paradigm of producing biologics. While the platform is potentially …
Engineering the plant secretory pathway for the production of next-generation pharmaceuticals
Production of biologics in plants, or plant molecular pharming, is a promising protein
expression technology that is receiving increasing attention from the pharmaceutical …
expression technology that is receiving increasing attention from the pharmaceutical …
Plant synthetic biology could drive a revolution in biofuels and medicine
JC Mortimer - Experimental Biology and Medicine, 2019 - journals.sagepub.com
Population growth, climate change, and dwindling finite resources are amongst the major
challenges which are facing the planet. Requirements for food, materials, water, and energy …
challenges which are facing the planet. Requirements for food, materials, water, and energy …
Human protein paucimannosylation: cues from the eukaryotic kingdoms
Paucimannosidic proteins (PMPs) are bioactive glycoproteins carrying truncated α‐or β‐
mannosyl‐terminating asparagine (N)‐linked glycans widely reported across the eukaryotic …
mannosyl‐terminating asparagine (N)‐linked glycans widely reported across the eukaryotic …
Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues
S Kallolimath, R Palt, E Föderl-Höbenreich… - Frontiers in …, 2023 - frontiersin.org
Immunoglobulin M (IgM) is the largest antibody isotype with unique features like extensive
glycosylation and oligomerization. Major hurdles in characterizing its properties are …
glycosylation and oligomerization. Major hurdles in characterizing its properties are …
An oligosaccharyltransferase from Leishmania major increases the N‐glycan occupancy on recombinant glycoproteins produced in Nicotiana benthamiana
A Castilho, G Beihammer, C Pfeiffer… - Plant Biotechnology …, 2018 - Wiley Online Library
N‐glycosylation is critical for recombinant glycoprotein production as it influences the
heterogeneity of products and affects their biological function. In most eukaryotes, the …
heterogeneity of products and affects their biological function. In most eukaryotes, the …
Reduced paucimannosidic N‐glycan formation by suppression of a specific β‐hexosaminidase from Nicotiana benthamiana
YJ Shin, A Castilho, M Dicker, F Sádio… - Plant biotechnology …, 2017 - Wiley Online Library
Plants are attractive hosts for the production of recombinant glycoproteins for therapeutic
use. Recent advances in glyco‐engineering facilitate the elimination of nonmammalian‐type …
use. Recent advances in glyco‐engineering facilitate the elimination of nonmammalian‐type …