Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade
cellular constituents and is often induced under cellular stress conditions to restore cell …

Ubiquitination is a widespread post-translational modification that controls multiple steps in
autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Autophagy is a highly conserved process and is essential for the maintenance of cellular
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …

Disrupting the balance between self-renewal and differentiation of hematopoietic stem cells
(HSCs) leads to bone marrow failure or hematologic malignancy. However, how HSCs …

Autophagy is a major degradative process activated in a rapid and transient manner to cope
with stress conditions. Whether autophagy is beneficial or detrimental depends upon the …

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC); however, the molecular mechanisms …