Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Mitochondria are critical organelles responsible for regulating the metabolic status of
skeletal muscle. These organelles exhibit remarkable plasticity by adapting their volume …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Background: p53 is a tumor suppressor protein involved in regulating a wide array of
signaling pathways. The role of p53 in the cell is determined by the type of imposed …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

The tumor suppressor protein p53 is a redox-active transcription factor that organizes and
directs cellular responses in the face of a variety of stresses that lead to genomic instability …

p53 is one of the most mutated tumor suppressors in human cancers and as such has been
intensively studied for a long time. p53 is a major orchestrator of the cellular response to a …