The complexity of p53-mediated metabolic regulation in tumor suppression
Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …
and apoptosis are well accepted as critical barriers to cancer development, accumulating …
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …
human cancers. p53 functions during cancer progression have been linked to a variety of …
Maintenance of skeletal muscle mitochondria in health, exercise, and aging
Mitochondria are critical organelles responsible for regulating the metabolic status of
skeletal muscle. These organelles exhibit remarkable plasticity by adapting their volume …
skeletal muscle. These organelles exhibit remarkable plasticity by adapting their volume …
Healthful aging mediated by inhibition of oxidative stress
SF Vatner, J Zhang, M Oydanich, T Berkman… - Ageing Research …, 2020 - Elsevier
The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …
related to the accompanying burden of debilitating diseases prevalent in the older …
Mechanisms of cisplatin nephrotoxicity
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …
limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has …
The mitochondrial pathways of apoptosis
Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …
A systematic review of p53 regulation of oxidative stress in skeletal muscle
K Beyfuss, DA Hood - Redox Report, 2018 - Taylor & Francis
Background: p53 is a tumor suppressor protein involved in regulating a wide array of
signaling pathways. The role of p53 in the cell is determined by the type of imposed …
signaling pathways. The role of p53 in the cell is determined by the type of imposed …
Direct cellular responses to platinum-induced DNA damage
Y Jung, SJ Lippard - Chemical reviews, 2007 - ACS Publications
Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …
ROS and p53: a versatile partnership
B Liu, Y Chen, DKS Clair - Free Radical Biology and Medicine, 2008 - Elsevier
The tumor suppressor protein p53 is a redox-active transcription factor that organizes and
directs cellular responses in the face of a variety of stresses that lead to genomic instability …
directs cellular responses in the face of a variety of stresses that lead to genomic instability …
[HTML][HTML] The mitochondrial p53 pathway
AV Vaseva, UM Moll - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2009 - Elsevier
p53 is one of the most mutated tumor suppressors in human cancers and as such has been
intensively studied for a long time. p53 is a major orchestrator of the cellular response to a …
intensively studied for a long time. p53 is a major orchestrator of the cellular response to a …