Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

It is becoming increasingly clear that virtually all types of human cancers harbor a small
population of stem-like cancer cells (ie, cancer stem cells, CSCs). These CSCs preexist in …

Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading
cause of cancer-related death for American men due to a subset of patients progressing to …

It is increasingly appreciated that cancer cell heterogeneity and plasticity constitute major
barriers to effective clinical treatments and long-term therapeutic efficacy. Research in the …

Prostate cancer is one of the most commonly diagnosed cancers in men, and androgen
deprivation therapy still represents the primary treatment for prostate cancer patients. This …

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory
mechanisms have evolved to maintain iron homeostasis within cells and between different …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most
common cause of cancer-related mortality among men in the developed world …

Due to the lack of effective strategies on the treatment of castration resistant prostate cancer
(CRPC), we established a multifunctional nanoplatform (GNS@ IR820/DTX-CD133) for the …

Purpose: We have shown that the phenotypically undifferentiated (PSA−/lo) prostate cancer
cell population harbors long-term self-renewing cancer stem cells (CSC) that resist …