CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications
C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10kDa (IP-
10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family …
10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family …
CXCL10 chemokine: a critical player in RNA and DNA viral infections
Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration
and contribute to their activation. Chemokines are crucial inflammatory mediators that play a …
and contribute to their activation. Chemokines are crucial inflammatory mediators that play a …
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
RE Lanford, ES Hildebrandt-Eriksen, A Petri… - Science, 2010 - science.org
The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA
accumulation in cultured liver cells, but its potential as a target for antiviral intervention has …
accumulation in cultured liver cells, but its potential as a target for antiviral intervention has …
HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons
BACKGROUND & AIMS: Polymorphisms in the IL28B gene have been associated with
clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV …
clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV …
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised …
EJ Gane, SK Roberts, CAM Stedman, PW Angus… - The Lancet, 2010 - thelancet.com
Background Present interferon-based standard of care treatment for chronic hepatitis C virus
(HCV) infection is limited by both efficacy and tolerability. We assessed the safety …
(HCV) infection is limited by both efficacy and tolerability. We assessed the safety …
[HTML][HTML] IP-10 is highly involved in HIV infection
J Lei, X Yin, H Shang, Y Jiang - Cytokine, 2019 - Elsevier
Abstract Interferon-γ (IFN-γ)-induced protein 10 (IP-10 or CXCL-10) is a chemokine involved
in trafficking immune cells to inflammatory sites. Numerous studies have reported …
in trafficking immune cells to inflammatory sites. Numerous studies have reported …
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV
A Casrouge, J Decalf, M Ahloulay… - The Journal of …, 2011 - Am Soc Clin Investig
Chronic infection with hepatitis C virus (HCV) is a major public health problem, with nearly
170 million infected individuals worldwide. Current treatment for chronic infection is a …
170 million infected individuals worldwide. Current treatment for chronic infection is a …
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection
S Dabo, EF Meurs - Viruses, 2012 - mdpi.com
The double-stranded RNA-dependent protein kinase PKR plays multiple roles in cells, in
response to different stress situations. As a member of the interferon (IFN)‑Stimulated …
response to different stress situations. As a member of the interferon (IFN)‑Stimulated …
[PDF][PDF] Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
The reasons for hepatitis C treatment failure remain unknown but may be related to different
host responses to therapy. In this study, we compared hepatic gene expression in patients …
host responses to therapy. In this study, we compared hepatic gene expression in patients …
Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection
K Giersch, L Allweiss, T Volz, M Helbig, J Bierwolf… - Journal of …, 2015 - Elsevier
Background & Aims The limited availability of hepatitis Delta virus (HDV) infection models
has hindered studies of interactions between HDV and infected hepatocytes. The aim was to …
has hindered studies of interactions between HDV and infected hepatocytes. The aim was to …