ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …

Complex processes are involved in the protection of cells and organisms by heat shock
proteins (hsps). Aberrant protein production due to high temperatures is prevented by the …

Members of the IL-6 cytokine family are involved in a variety of biological responses,
including the immune response, inflammation, hematopoiesis, and oncogenesis by …

Proteins modified by multiubiquitin chains are the preferred substrates of the proteasome.
Ubiquitination involves a ubiquitin-activating enzyme, E1, a ubiquitin-conjugating enzyme …

A Saccharomyces cerevisiae mutant in cell division cycle gene CDC48 shows typical
markers of apoptosis: membrane staining with annexin V, indicating an exposure of …

Saccharomyces cerevisiae cells treated with the immunosuppressant rapamycin or depleted
for the targets of rapamycin TOR1 and TOR2 arrest growth in the early G1 phase of the cell …

In this work, we review clinical features and genetic diagnosis of diseases caused by
mutations in the gene encoding valosin-containing protein (VCP/p97), the functionally …

Profilins are small actin-binding proteins that are essential in all organisms that have been
examined to date. In vitro, profilins regulate the dynamics of actin polymerization, which is …

Endoplasmic reticulum-associated degradation (ERAD) disposes of aberrant proteins in the
secretory pathway. Protein substrates of ERAD are dislocated via the Sec61p translocon …

At least two distinct ATPases, NSF and p97, are known to be involved in the heterotypic
fusion of transport vesicles with their target membranes and the homotypic fusion of …