Memory engrams: Recalling the past and imagining the future

SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

[HTML][HTML] Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

A Guskjolen, MS Cembrowski - Molecular psychiatry, 2023 - nature.com
Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …

Encouraging an excitable brain state: mechanisms of brain repair in stroke

MT Joy, ST Carmichael - Nature Reviews Neuroscience, 2021 - nature.com
Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …

A shared neural ensemble links distinct contextual memories encoded close in time

DJ Cai, D Aharoni, T Shuman, J Shobe, J Biane… - Nature, 2016 - nature.com
Recent studies suggest that a shared neural ensemble may link distinct memories encoded
close in time,,,,,,,,,,,. According to the memory allocation hypothesis,, learning triggers a …

Finding the engram

SA Josselyn, S Köhler, PW Frankland - Nature Reviews Neuroscience, 2015 - nature.com
Many attempts have been made to localize the physical trace of a memory, or engram, in the
brain. However, until recently, engrams have remained largely elusive. In this Review, we …

Fear memory

I Izquierdo, CRG Furini, JC Myskiw - Physiological reviews, 2016 - journals.physiology.org
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …

The neurobiological foundation of memory retrieval

PW Frankland, SA Josselyn, S Köhler - Nature neuroscience, 2019 - nature.com
Memory retrieval involves the interaction between external sensory or internally generated
cues and stored memory traces (or engrams) in a process termed 'ecphory'. While ecphory …

DREADDS: Use and application in behavioral neuroscience.

KS Smith, DJ Bucci, BW Luikart… - Behavioral …, 2016 - psycnet.apa.org
Technological advances over the last decade are changing the face of behavioral
neuroscience research. Here we review recent work on the use of one such transformative …

CCR5 closes the temporal window for memory linking

Y Shen, M Zhou, D Cai, DA Filho, G Fernandes, Y Cai… - Nature, 2022 - nature.com
Real-world memories are formed in a particular context and are often not acquired or
recalled in isolation,,,–. Time is a key variable in the organization of memories, as events …

[图书][B] Broken movement: the neurobiology of motor recovery after stroke

JW Krakauer, ST Carmichael - 2022 - books.google.com
An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …