Cancer represents an evolutionary process through which growing malignant populations
genetically diversify, leading to tumour progression, relapse and resistance to therapy. In …

Ductal carcinoma in situ (DCIS) is an early-stage breast cancer that infrequently progresses
to invasive ductal carcinoma (IDC). Genomic evolution has been difficult to delineate during …

Myelodysplastic syndromes (MDS) frequently progress to acute myeloid leukemia (AML);
however, the cells leading to malignant transformation have not been directly elucidated. As …

It has become increasingly clear that both normal and cancer tissues are composed of
heterogeneous populations. Genetic variation can be attributed to the downstream effects of …

PD-1 blockade exerts clinical efficacy against various types of cancer by reinvigorating T
cells that directly attack tumor cells (tumor-specific T cells) in the tumor microenvironment …

Cancer cell lines are not homogeneous nor are they static in their genetic state and
biological properties. Genetic, transcriptional and phenotypic diversity within cell lines …

Measuring gene expression of tumor clones at single-cell resolution links functional
consequences to somatic alterations. Without scalable methods to simultaneously assay …

Clonal evolution in myelodysplastic syndrome (MDS) can result in clinical progression and
secondary acute myeloid leukemia (sAML). To dissect changes in clonal architecture …

Purpose: Targeted therapy and immunotherapy are transforming the treatment approach for
intrahepatic cholangiocarcinoma (ICC). However, little is known about the intertumor …

Single-cell whole-exome sequencing (scWES) is a powerful approach for deciphering
intratumor heterogeneity and identifying cancer drivers. So far, however, simultaneous …