Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

The intimate connection, both physical and biochemical, between blood vessels and bone
cells has long been recognized. Genetic, biochemical, and pharmacological studies have …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

The therapeutic use of autologous platelet-rich plasma constitutes a relatively new
biotechnology that has been a breakthrough in the stimulation and acceleration of soft-tissue …

Blood platelets become activated and aggregate at the site of vessel injury. Upon activation
by thrombin, platelets release storage pools of proteins and growth factors (GFs), including …

The abilities of bone to remodel, fractures to repair, and bone grafts to incorporate are all
fundamental reflections of the bone remodeling cycle. This process is characterized by the …

This human clinical trial evaluated the clinical and histologic response to recombinant
human platelet-derived growth factor-BB (rhPDGF-BB) delivered in bone allograft for the …

Increased osteoclastogenesis and angiogenesis occur in physiologic and pathologic
conditions. However, it is unclear if or how these processes are linked. To test the …

Limitations of current treatment options for critical size bone defects create a significant
clinical need for tissue engineered bone strategies. This review describes how control over …

The primary goal of regenerative endodontics is to restore the vitality and functions of the
dentin-pulp complex, as opposed to filing of the root canal with bioinert materials. A myriad …