Indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophan 2, 3-dioxygenase 2 (TDO2) catalyze
the commitment step of the kynurenine (KYN) metabolic pathway. Traditionally the …

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …

The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the
pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2, 3 …

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell
(HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased …

Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other
autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl …

The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …

Recent studies have shown an association between maternal exposure to ambient fine
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the
toxic activity of many environmental xenobiotics. However, its role in innate immune …

Whether tobacco carcinogens enable exposed cells immune escape resulting in
carcinogenesis, and why patients who smoke respond better to immunotherapies than non …

Th17 cell differentiation is dependent on interleukin (IL)-6 and transforming growth factor
(TGF)-β, and it is modulated by activation of the aryl hydrocarbon receptor (AhR). In this …