Targeting the IDO1/TDO2–KYN–AhR pathway for cancer immunotherapy–challenges and opportunities
JE Cheong, L Sun - Trends in pharmacological sciences, 2018 - cell.com
Indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophan 2, 3-dioxygenase 2 (TDO2) catalyze
the commitment step of the kynurenine (KYN) metabolic pathway. Traditionally the …
the commitment step of the kynurenine (KYN) metabolic pathway. Traditionally the …
Aryl hydrocarbon receptor ligands in cancer: friend and foe
IA Murray, AD Patterson, GH Perdew - Nature Reviews Cancer, 2014 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …
The aryl hydrocarbon receptor: multitasking in the immune system
B Stockinger, PD Meglio, M Gialitakis… - Annual review of …, 2014 - annualreviews.org
The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the
pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2, 3 …
pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2, 3 …
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
AE Boitano, J Wang, R Romeo, LC Bouchez, AE Parker… - Science, 2010 - science.org
Although practiced clinically for more than 40 years, the use of hematopoietic stem cell
(HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased …
(HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased …
Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions
Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other
autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl …
autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl …
The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology
C Esser, A Rannug - Pharmacological reviews, 2015 - ASPET
The aryl hydrocarbon receptor (AhR) is an evolutionarily old transcription factor belonging to
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …
the Per-ARNT-Sim–basic helix-loop-helix protein family. AhR translocates into the nucleus …
AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2. 5 in zebrafish embryos
F Ren, C Ji, Y Huang, S Aniagu, Y Jiang… - Science of the Total …, 2020 - Elsevier
Recent studies have shown an association between maternal exposure to ambient fine
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …
Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense
T Yamada, H Horimoto, T Kameyama, S Hayakawa… - Nature …, 2016 - nature.com
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the
toxic activity of many environmental xenobiotics. However, its role in innate immune …
toxic activity of many environmental xenobiotics. However, its role in innate immune …
The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
GZ Wang, L Zhang, XC Zhao, SH Gao, LW Qu… - Nature …, 2019 - nature.com
Whether tobacco carcinogens enable exposed cells immune escape resulting in
carcinogenesis, and why patients who smoke respond better to immunotherapies than non …
carcinogenesis, and why patients who smoke respond better to immunotherapies than non …
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
M Veldhoen, K Hirota, J Christensen… - Journal of Experimental …, 2009 - rupress.org
Th17 cell differentiation is dependent on interleukin (IL)-6 and transforming growth factor
(TGF)-β, and it is modulated by activation of the aryl hydrocarbon receptor (AhR). In this …
(TGF)-β, and it is modulated by activation of the aryl hydrocarbon receptor (AhR). In this …