Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Developing small molecules that modulate protein …

Antibodies are highly specific, naturally evolved molecules that recognize and eliminate
pathogenic and disease antigens. The past 30 years of antibody research have hinted at the …

Abstract abYsis is a web-based antibody research system that includes an integrated
database of antibody sequence and structure data. The system can be interrogated in …

Nanobodies are the smallest fragments of naturally occurring heavy-chain antibodies that
have evolved to be fully functional in the absence of a light chain. As such, the cloning and …

Much of the 25 years since Kohler and Milstein first described making monoclonal
antibodies (mAbs) has been spent trying to develop these reagents to treat human disease …

Improvements in surgical techniques and availability of immunosuppressive options have
led to current successes in the arena of solid organ transplantation. Historically …

Primary immune thrombocytopenic purpura (ITP), also referred to as idiopathic
thrombocytopenic purpura, is an organ-specific autoimmune disorder in which …

T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through
binding to its corresponding cell surface receptor. Three forms of the receptor are …

Purpose Induction immunosuppressive therapies for patients undergoing renal
transplantation are reviewed. Summary The goal of induction therapy is to prevent acute …

The idea of replacing diseased organs has been around since the 18th century. 1 In 1933,
the first recorded human cadaveric transplant was performed in Russia by Yurii Voronoy. 2 …