The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting
J Wykosky, W Debinski - Molecular Cancer Research, 2008 - AACR
The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …
their roles in developmental processes. In recent years, Eph receptors and ephrins have …
Mechanisms of endothelial cell migration
UR Michaelis - Cellular and molecular life sciences, 2014 - Springer
Cell migration plays a central role in a variety of physiological and pathological processes
during our whole life. Cellular movement is a complex, tightly regulated multistep process …
during our whole life. Cellular movement is a complex, tightly regulated multistep process …
Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein–protein binding free energies and re-rank binding poses …
Understanding protein–protein interactions (PPIs) is quite important to elucidate crucial
biological processes and even design compounds that interfere with PPIs with …
biological processes and even design compounds that interfere with PPIs with …
Germline loss-of-function mutations in EPHB4 cause a second form of capillary malformation-arteriovenous malformation (CM-AVM2) deregulating RAS-MAPK …
Background: Most arteriovenous malformations (AVMs) are localized and occur
sporadically. However, they also can be multifocal in autosomal-dominant disorders, such …
sporadically. However, they also can be multifocal in autosomal-dominant disorders, such …
[图书][B] Introduction to proteins: structure, function, and motion
Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
structure, function, and motion of proteins for students, faculty, and researchers at all levels …
Assessing the performance of the MM/PBSA and MM/GBSA methods. 10. Impacts of enhanced sampling and variable dielectric model on protein–protein interactions
Enhanced sampling has been extensively used to capture the conformational transitions in
protein folding, but it attracts much less attention in the studies of protein–protein …
protein folding, but it attracts much less attention in the studies of protein–protein …
Are scoring functions in protein− protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark
PL Kastritis, AMJJ Bonvin - Journal of proteome research, 2010 - ACS Publications
The design of an ideal scoring function for protein− protein docking that would also predict
the binding affinity of a complex is one of the challenges in structural proteomics. Such a …
the binding affinity of a complex is one of the challenges in structural proteomics. Such a …
Cell–cell signaling via Eph receptors and ephrins
JP Himanen, N Saha, DB Nikolov - Current opinion in cell biology, 2007 - Elsevier
Eph receptors are the largest subfamily of receptor tyrosine kinases regulating cell shape,
movements, and attachment. The interactions of the Ephs with their ephrin ligands are …
movements, and attachment. The interactions of the Ephs with their ephrin ligands are …
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
E Seiradake, K Harlos, G Sutton, AR Aricescu… - Nature structural & …, 2010 - nature.com
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases
mediating cell-cell communication. Upon activation, they form signaling clusters. We report …
mediating cell-cell communication. Upon activation, they form signaling clusters. We report …
Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2
TA Bowden, AR Aricescu, RJC Gilbert… - Nature structural & …, 2008 - nature.com
Nipah and Hendra viruses are emergent paramyxoviruses, causing disease characterized
by rapid onset and high mortality rates, resulting in their classification as Biosafety Level 4 …
by rapid onset and high mortality rates, resulting in their classification as Biosafety Level 4 …