The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting

J Wykosky, W Debinski - Molecular Cancer Research, 2008 - AACR
The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

Mechanisms of endothelial cell migration

UR Michaelis - Cellular and molecular life sciences, 2014 - Springer
Cell migration plays a central role in a variety of physiological and pathological processes
during our whole life. Cellular movement is a complex, tightly regulated multistep process …

Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein–protein binding free energies and re-rank binding poses …

F Chen, H Liu, H Sun, P Pan, Y Li, D Li… - Physical Chemistry …, 2016 - pubs.rsc.org
Understanding protein–protein interactions (PPIs) is quite important to elucidate crucial
biological processes and even design compounds that interfere with PPIs with …

Germline loss-of-function mutations in EPHB4 cause a second form of capillary malformation-arteriovenous malformation (CM-AVM2) deregulating RAS-MAPK …

M Amyere, N Revencu, R Helaers, E Pairet, E Baselga… - Circulation, 2017 - Am Heart Assoc
Background: Most arteriovenous malformations (AVMs) are localized and occur
sporadically. However, they also can be multifocal in autosomal-dominant disorders, such …

[图书][B] Introduction to proteins: structure, function, and motion

A Kessel, N Ben-Tal - 2018 - taylorfrancis.com
Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Assessing the performance of the MM/PBSA and MM/GBSA methods. 10. Impacts of enhanced sampling and variable dielectric model on protein–protein interactions

E Wang, G Weng, H Sun, H Du, F Zhu… - Physical Chemistry …, 2019 - pubs.rsc.org
Enhanced sampling has been extensively used to capture the conformational transitions in
protein folding, but it attracts much less attention in the studies of protein–protein …

Are scoring functions in protein− protein docking ready to predict interactomes? Clues from a novel binding affinity benchmark

PL Kastritis, AMJJ Bonvin - Journal of proteome research, 2010 - ACS Publications
The design of an ideal scoring function for protein− protein docking that would also predict
the binding affinity of a complex is one of the challenges in structural proteomics. Such a …

Cell–cell signaling via Eph receptors and ephrins

JP Himanen, N Saha, DB Nikolov - Current opinion in cell biology, 2007 - Elsevier
Eph receptors are the largest subfamily of receptor tyrosine kinases regulating cell shape,
movements, and attachment. The interactions of the Ephs with their ephrin ligands are …

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

E Seiradake, K Harlos, G Sutton, AR Aricescu… - Nature structural & …, 2010 - nature.com
Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases
mediating cell-cell communication. Upon activation, they form signaling clusters. We report …

Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

TA Bowden, AR Aricescu, RJC Gilbert… - Nature structural & …, 2008 - nature.com
Nipah and Hendra viruses are emergent paramyxoviruses, causing disease characterized
by rapid onset and high mortality rates, resulting in their classification as Biosafety Level 4 …