Current approaches and developments in transcript profiling of the human placenta

HEJ Yong, SY Chan - Human reproduction update, 2020 - academic.oup.com
BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …

[HTML][HTML] Alternative splicing of lncRNAs in human diseases

J Chen, Y Liu, J Min, H Wang, F Li, C Xu… - American journal of …, 2021 - ncbi.nlm.nih.gov
Alternative splicing (AS), a vital post-transcription process for eukaryote gene expression
regulating, can efficiently improve gene utilization and increase the variety of RNA …

Transcriptional regulation: Molecules, involved mechanisms, and misregulation

A Casamassimi, A Ciccodicola - International journal of molecular …, 2019 - mdpi.com
Transcriptional regulation is a critical biological process that allows the cell or an organism
to respond to a variety of intra-and extra-cellular signals, to define cell identity during …

Placenta transcriptome profiling in intrauterine growth restriction (IUGR)

M Majewska, A Lipka, L Paukszto… - International journal of …, 2019 - mdpi.com
Intrauterine growth restriction (IUGR) is a serious pathological complication associated with
compromised fetal development during pregnancy. The aim of the study was to broaden …

Preeclampsia-associated lncRNA INHBA-AS1 regulates the proliferation, invasion, and migration of placental trophoblast cells

S Jiang, Q Chen, H Liu, Y Gao, X Yang, Z Ren… - … Therapy-Nucleic Acids, 2020 - cell.com
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast
invasion, leading to impaired uterine spiral artery remodeling and angiogenesis. However …

The role of non-coding RNAs in the human placenta

M Žarković, F Hufsky, UR Markert, M Marz - Cells, 2022 - mdpi.com
Non-coding RNAs (ncRNAs) play a central and regulatory role in almost all cells, organs,
and species, which has been broadly recognized since the human ENCODE project and …

[HTML][HTML] Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

O Solomon, K Huen, P Yousefi, LK Küpers… - … Research/Reviews in …, 2022 - Elsevier
Background Among children, sex-specific differences in disease prevalence, age of onset,
and susceptibility have been observed in health conditions including asthma, immune …

Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia

H Fallah, I Azari, SM Neishabouri, VK Oskooei… - Scientific reports, 2019 - nature.com
Schizophrenia as a common disabling psychiatric disorder has been associated with
dysregulation of several genes and pathways among them are those being regulated by …

Silencing TTTY15 mitigates hypoxia-induced mitochondrial energy metabolism dysfunction and cardiomyocytes apoptosis via TTTY15/let-7i-5p and TLR3/NF-κB …

H Zhang, X Zou, F Liu - Cellular Signalling, 2020 - Elsevier
Noncoding RNAs are interweaved in pathological processes in myocardial ischemia (MI),
such as long noncoding RNA (lncRNA) and microRNAs (miRNAs). The aim of this study was …

Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing

L Dong, X Xin, HM Chang, PCK Leung, C Yu… - Journal of Ovarian …, 2022 - Springer
Background Infertility is a global reproductive-health problem, and diminished ovarian
reserve (DOR) is one of the common causes of female infertility. Long noncoding RNAs …