Insulin-dependent diabetes mellitus (IDDM) is a chronic disorder that results from
autoimmune destruction of the insulin-producing pancreatic beta cells. Much has been …

Publisher Summary This chapter summarizes the experimental findings and observations
based on the nonobese diabetic (NOD) mouse model and discusses the pathogenesis and …

Background and Methods Type 1 diabetes mellitus is now classified as autoimmune (type
1A) or idiopathic (type 1B), but little is known about the latter. We classified 56 consecutive …

Islet cell antibodies (ICAs) are predictive of type I diabetes in first-degree relatives, but this
immunohistochemical assay has proven difficult to standardize. As an alternative, we …

Background It is unknown whether insulin therapy can delay or prevent diabetes in
nondiabetic relatives of patients with diabetes. Methods In a randomized, controlled …

While patients with liver disease are known to have a higher prevalence of glucose
intolerance, preliminary studies suggest that hepatitis C virus (HCV) infection may be an …

Automated control of blood glucose (BG) concentration is a long-sought goal for type 1
diabetes therapy. We have developed a closed-loop control system that uses frequent …

Pancreatic islet autoimmunity leading to type 1 diabetes could be triggered by viruses in
genetically susceptible individuals. Rotavirus (RV), the most common cause of childhood …

Epidemiological studies have demonstrated an association between intrauterine growth
retardation and an increased risk of adult diseases that include essential hypertension …

With the development of an insulin autoantibody (IAA) assay performed in 96-well filtration
plates, we have evaluated prospectively the development of IAA in NOD mice (from 4 weeks …