A systematic review was conducted, summarizing international BRCA 1 or 2 (BRCA1/2)
mutation prevalence in breast cancer. Databases (eg, Medline and Embase; N= 7) and …

The breast cancer susceptibility gene (BRCA) is an important tumor suppressor gene,
including BRCA1 and BRCA2, a biomarker that assesses the risk of breast cancer and …

Abstract The Korean Hereditary Breast Cancer (KOHBRA) study was established to evaluate
the prevalence and spectrum of BRCA1/2 mutations in Korean breast cancer patients at risk …

Breast cancer is the most prevalent cancer in Asian females, and the incidence of breast
cancer has been increasing in Asia. Be cause Asian patients develop breast cancer at a …

Background To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations
in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to …

Background Pathogenic germline mutations in BRCA1 and BRCA2 (BRCA1/2) account for
the majority of hereditary breast and/or ovarian cancers worldwide. To refine the spectrum of …

The conservative nature of animal evolution makes animal models the ideal tool for learning
about human biology. The Handbook of Laboratory Animal Science, Second Edition: Animal …

Abstract Genetic susceptibility explains 5–10% of all breast cancer cases. High-penetrance
breast cancer susceptibility genes deliberate a greater than tenfold relative risk of breast …

The identification and interpretation of germline BRCA1/2 variants become increasingly
important in breast and ovarian cancer (OC) treatment. However, there is no comprehensive …

It has been shown that the loss of function of the BRCA1, BRCA2, and PALB2 genes due to
a number of hereditary mutations or chromosomal aberrations can affect the effectiveness of …