The Future of Carica papaya Leaf Extract as an Herbal Medicine Product

M Hariono, J Julianus, I Djunarko, I Hidayat, L Adelya… - Molecules, 2021 - mdpi.com
Carica papaya (papaya) leaf extract has been used for a long time in a traditional medicine
to treat fever in some infectious diseases such as dengue, malaria, and chikungunya. The …

GC-MS, LC-MS/MS, Docking and Molecular Dynamics Approaches to Identify Potential SARS-CoV-2 3-Chymotrypsin-Like Protease Inhibitors from Zingiber officinale …

MS Zubair, S Maulana, A Widodo, R Pitopang, M Arba… - Molecules, 2021 - mdpi.com
This study aims to identify and isolate the secondary metabolites of Zingiber officinale using
GC-MS, preparative TLC, and LC-MS/MS methods, to evaluate the inhibitory potency on …

Morelloflavone as Phytomedicine-An Ethnopharmacological Review on the Therapeutical Properties, Biological Efficacy and Pharmacological Activity

DK Patel - Anti-Infective Agents, 2023 - ingentaconnect.com
Background: Flavonoids are low molecular weight class secondary metabolites found to be
present throughout the plant kingdom. Structurally, flavonoid class phytochemicals consist of …

[HTML][HTML] Potential SARS-CoV-2 3CLpro inhibitors from chromene, flavonoid and hydroxamic acid compound based on FRET assay, docking and pharmacophore …

M Hariono, P Hariyono, R Dwiastuti, W Setyani… - Results in chemistry, 2021 - Elsevier
This present study reports some natural products and one hydroxamic acid synthetic
compound which were previously reported as matrix metalloproteinase-9 (MMP-9) inhibitors …

[HTML][HTML] Agathisflavone, a natural biflavonoid that inhibits SARS-CoV-2 replication by targeting its proteases

OA Chaves, CR Lima, N Fintelman-Rodrigues… - International Journal of …, 2022 - Elsevier
Despite the fast development of vaccines, the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) still circulates through variants of concern (VoC) and escape …

Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mpro) Autocleavage Enzyme Critical for COVID-19 Pathogenesis

SAG Naidu, YB Tripathi, P Shree… - Journal of Dietary …, 2023 - Taylor & Francis
The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2
pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control …

Evaluation of inhibition effect and interaction mechanism of antiviral drugs on main protease of novel coronavirus: Molecular docking and molecular dynamics studies

X Gao, C Wang, Y Jiang, S Zhang, M Zhang… - Journal of Molecular …, 2024 - Elsevier
The outbreak of pneumonia caused by the novel coronavirus (SARS-CoV-2) has presented
a challenge to public health. The identification and development of effective antiviral drugs is …

[HTML][HTML] 2-Phenoxyacetamide derivatives as SARS-CoV-2 main protease inhibitor: In silico studies

P Hariyono, R Dwiastuti, M Yusuf, NH Salin… - Results in …, 2022 - Elsevier
Phenoxyacetamide group has been identified as one of markers in the discovery and
development of SARS-CoV-2 antiviral agent through its main protease (M pro) inhibition …

Nanostructured biohybrid material with wide-ranging antiviral action

N Losada-Garcia, A Vazquez-Calvo, D Ortega-Alarcon… - Nano Research, 2023 - Springer
Respiratory pathogens kill more people than any other infectious agent each year
worldwide. Development of novel, economically friendly, sustainable, and highly efficient …

[PDF][PDF] Studi In Silico Aktivitas Analog Senyawa Zizyphine dari Bidara Arab (Zizyphus spina-christi) sebagai Antivirus SARS-CoV-2 terhadap Reseptor 3CLpro

TM Fakih, FA Jannati, A Meilani… - ALCHEMY Jurnal …, 2022 - researchgate.net
COVID-19 merupakan penyakit yang penularannya human to human yang pertama kali
ditemukan di China (Kota Wuhan). Tanaman bidara arab mengandung banyak metabolit …