Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke

L Nie, D Yao, S Chen, J Wang, C Pan, D Wu… - Cell Death …, 2023 - nature.com
Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

Neurite outgrowth and gene expression profile correlate with efficacy of human induced pluripotent stem cell-derived dopamine neuron grafts

R Hills, JA Mossman, AM Bratt-Leal, H Tran… - Stem cells and …, 2023 - liebertpub.com
Transplantation of human induced pluripotent stem cell-derived dopaminergic (iPSC-DA)
neurons is a promising therapeutic strategy for Parkinson's disease (PD). To assess optimal …

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo

J Rájová, M Davidsson, M Avallone, M Hartnor… - … Therapy Methods & …, 2023 - cell.com
Cell therapy for Parkinson's disease has experienced substantial growth in the past decades
with several ongoing clinical trials. Despite increasing refinement of differentiation protocols …

Human stem cell transplantation for Parkinson's disease: A systematic review of in situ survival and maturation of progenitors derived from human embryonic or …

G Comini, E Dowd - bioRxiv, 2024 - biorxiv.org
Stem cell-based brain repair is a promising emergent therapy for Parkinson's which is based
on years of foundational research using human fetal donors as a cell source. Unlike current …

Investigating the role of dopamine in cognitive impairments in a rat model of Parkinson's Disease

C Bridge - 2023 - orca.cardiff.ac.uk
Thesis Summary Non-motor symptoms are a major component of Parkinson's Disease and
have a significant impact on quality of life. Outcome measures of pre-clinical studies …