Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

BACKGROUND Endometriosis, a common oestrogen-dependent inflammatory disorder in
women of reproductive age, is characterized by endometrial-like tissue outside its normal …

The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

OA is a painful joint disease that predominantly affects the elderly. Pain is the primary
symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Cognitive impairment is commonly associated with the pain experience. This impairment
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …

Although microglia have long been considered as brain resident immune cells, increasing
evidence suggests that they also have physiological roles in the development of the normal …

Neuropathic pain resulting from damage or dysfunction of the nervous system is a highly
debilitating chronic pain state and is often resistant to currently available treatments. It has …