[HTML][HTML] Impact of the natural compound urolithin A on health, disease, and aging
D D'Amico, PA Andreux, P Valdés, A Singh… - Trends in molecular …, 2021 - cell.com
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …
A review of gut microbiota‐derived metabolites in tumor progression and cancer therapy
Q Yang, B Wang, Q Zheng, H Li, X Meng… - Advanced …, 2023 - Wiley Online Library
Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …
progression, primarily by remodeling the tumor microenvironment and regulating key …
[HTML][HTML] Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
D Denk, V Petrocelli, C Conche, M Drachsler… - Immunity, 2022 - cell.com
T memory stem cells (T SCM) display increased self-renewal and prolonged survival
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …
capabilities, thus preventing T cell exhaustion and promoting effective anti-tumor T cell …
Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer
We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded
microenvironments, chemoresistance, and poor survival in pancreatic ductal …
microenvironments, chemoresistance, and poor survival in pancreatic ductal …
Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation
M Zhang, S Cui, B Mao, Q Zhang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …
Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy
M Beygi, F Oroojalian, SS Hosseini… - Progress in Materials …, 2023 - Elsevier
The majority of advances in cancer therapy have been achieved based on developments in
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …
The impact of ellagitannins and their metabolites through gut microbiome on the gut health and brain wellness within the gut–brain axis
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods,
such as pomegranates, berries, and nuts. The consumption of ETs has often been …
such as pomegranates, berries, and nuts. The consumption of ETs has often been …
Punicalagin regulates signaling pathways in inflammation-associated chronic diseases
Inflammation is a complex biological defense system associated with a series of chronic
diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative …
diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative …
[HTML][HTML] Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis
The survival rate of colorectal cancer patients is adversely affected by the selection of tumors
resistant to conventional anti-cancer drugs such as 5-fluorouracil (5FU). Although there is …
resistant to conventional anti-cancer drugs such as 5-fluorouracil (5FU). Although there is …
Targeting PI3K pathway in pancreatic ductal adenocarcinoma: rationale and progress
Simple Summary Pancreatic cancer has a dismal 5-year survival rate of 10%, making it one
of the deadliest forms of malignancy. The poor prognosis associated with this disease is …
of the deadliest forms of malignancy. The poor prognosis associated with this disease is …