DNA polymerase theta (pol θ) is encoded in the genomes of many eukaryotes, though not in
fungi. Pol θ is encoded by the POLQ gene in mammalian cells. The C-terminal third of the …

DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA
repair and damage tolerance, including double-strand break repair and DNA translesion …

DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the
repair of chromosome breaks, but its cellular mechanism and role relative to canonical …

The current study aimed to identify new breast and/or ovarian cancer predisposition genes.
For that, whole‐exome sequencing (WES) was performed in the germline DNA of 52 non …

Background The 5-year survival rate of patients with pancreatic ductal adenocarcinoma
(PDAC) is around 5% due to the fact that the majority of patients present with advanced …

DNA polymerase theta (Pol θ) is an error-prone A-family polymerase that is highly
conserved among multicellular eukaryotes and plays multiple roles in DNA repair and the …

DNA damage can lead to erroneous alterations and mutations which in turn can result into
wide range of disease condition including aging, severe inflammation, and, most …

DNA repair processes are involved in both the onset and treatment efficacy of colorectal
cancer (CRC). A change of a single nucleotide causing an amino acid substitution in the …

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes are present in about 50% of
cases of hereditary breast cancer. Proteins encoded by these genes are key players in DNA …

Familial pancreatic cancer (FPC) is an established but rare inherited tumor syndrome that
accounts for approximately 5% of pancreatic ductal adenocarcinoma (PDAC) cases. No …