Next-generation approaches to understand and combat the antibiotic resistome
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
Plasmid-mediated quinolone resistance: two decades on
JM Rodríguez-Martínez, J Machuca, ME Cano… - Drug Resistance …, 2016 - Elsevier
After two decades of the discovery of plasmid-mediated quinolone resistance (PMQR), three
different mechanisms have been associated to this phenomenon: target protection (Qnr …
different mechanisms have been associated to this phenomenon: target protection (Qnr …
Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes
Background Bacterial communities in humans, animals, and the external environment
maintain a large collection of antibiotic resistance genes (ARGs). However, few of these …
maintain a large collection of antibiotic resistance genes (ARGs). However, few of these …
Prevalence, antimicrobial resistance (AMR) pattern, virulence determinant and AMR genes of emerging multi-drug resistant Edwardsiella tarda in Nile tilapia and …
Edwardsiella tarda is a common fish pathogen, causing septicemic diseases and formidable
economic losses in freshwater fish farming. This study aimed to investigate the prevalence …
economic losses in freshwater fish farming. This study aimed to investigate the prevalence …
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India
There is increasing evidence for an environmental origin of many antibiotic resistance
genes. Consequently, it is important to identify environments of particular risk for selecting …
genes. Consequently, it is important to identify environments of particular risk for selecting …
Occurrence of Salmonella enterica and Escherichia coli in raw chicken and beef meat in northern Egypt and dissemination of their antibiotic resistance markers
AA Moawad, H Hotzel, O Awad, H Tomaso… - Gut pathogens, 2017 - Springer
Background The global incidence of foodborne infections and antibiotic resistance is
recently increased and considered of public health concern. Currently, scarcely information …
recently increased and considered of public health concern. Currently, scarcely information …
Discovery of the fourth mobile sulfonamide resistance gene
M Razavi, NP Marathe, MR Gillings, CF Flach… - Microbiome, 2017 - Springer
Background Over the past 75 years, human pathogens have acquired antibiotic resistance
genes (ARGs), often from environmental bacteria. Integrons play a major role in the …
genes (ARGs), often from environmental bacteria. Integrons play a major role in the …
Identification and reconstruction of novel antibiotic resistance genes from metagenomes
Background Environmental and commensal bacteria maintain a diverse and largely
unknown collection of antibiotic resistance genes (ARGs) that, over time, may be mobilized …
unknown collection of antibiotic resistance genes (ARGs) that, over time, may be mobilized …
Sewage effluent from an Indian hospital harbors novel carbapenemases and integron-borne antibiotic resistance genes
Background Hospital wastewaters contain fecal material from a large number of individuals,
of which many are undergoing antibiotic therapy. It is, thus, plausible that hospital …
of which many are undergoing antibiotic therapy. It is, thus, plausible that hospital …
Resistance Mutations in gyrA and parC are Common in Escherichia Communities of both Fluoroquinolone-Polluted and Uncontaminated Aquatic Environments
Alterations in the target proteins of fluoroquinolones, especially in GyrA and ParC, are
known to cause resistance. Here, we investigated environmental Escherichia communities …
known to cause resistance. Here, we investigated environmental Escherichia communities …