Cell survival or death is one critical issue in inflammatory responses. Ferroptosis, which is
characterized by iron-dependent lethal lipid peroxidation, has been found to participate in …

Microbes exert a major impact on human health and disease by either promoting or
disrupting homeostasis, in the latter instance leading to the development of infectious …

Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …

Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide
due to a single infectious agent. Despite chemotherapy, the global tuberculosis epidemic …

Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the
host biomarkers appears to play a significant role. The currently available diagnostic …

Iron metabolism is vital for the survival of both humans and microorganisms. Heme
oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs …

More efficacious treatment regimens are needed for tuberculosis, however, drug
development is impeded by a lack of reliable biomarkers of disease severity and of …

New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools
for diagnosis and new biomarkers are required to evaluate both pathogen and host key …

Background Metformin, by reducing intracellular Mycobacterium tuberculosis growth, can be
considered an adjunctive therapy to anti-tuberculosis treatment (ATT). We determined …

Although autophagy sequesters Mycobacterium tuberculosis (Mtb) in in vitro cultured
macrophages, loss of autophagy in macrophages in vivo does not result in susceptibility to a …